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    2. 科研成果

      生命學院代表性論文

      • Structures of the catalytically activated yeast spliceosome reveal the mechanism of branching.

        Wan, Ruixue; Bai, Rui; Yan, Chuangye; Lei, Jianlin; Shi, Yigong.

        CELL 2019, 177 (2): 339-351.

      • Structural basis of Notch recognition by human γ-secretase.

        Guanghui Yang, Rui Zhou, Qiang Zhou, Xuefei Guo, Chuangye Yan, Meng Ke, Jianlin Lei, Yigong Shi.

        NATURE 2019,565 (7738): 192–197.

      • P53 regulation of ammonia metabolism through urea cycle controls polyamine biosynthesis.

        Li, Le; Mao, Youxiang; Zhao, Lina; Li, Lijia; Wu, Jinjun; Zhao, Mengjia; Du, Wenjing; Yu, Li; Jiang, Peng.

        NATURE 2019, 567 (7747): 253–256

      • Mechanism of DNA translocation underlying chromatin remodelling by Snf2.

        Li, Meijing; Xia, Xian; Tian, Yuanyuan; Jia, Qi; Liu, Xiaoyu; Lu, Ying; Li, Ming; Li, Xueming; Chen, Zhucheng.

        NATURE 2019, 567 (7748): 409–413.

      • Mechanisms of RALF peptide perception by a heterotypic receptor complex.

        Xiao, Yu; Stegmann, Martin; Han, Zhifu; DeFalco, Thomas A.; Parys, Katarzyna; Xu, Li; Belkhadir, Youssef; Zipfel, Cyril; Chai, Jijie.

        NATURE 2019, 572 (7768): 270–274.

      • Recognition of the amyloid precursor protein by human gamma-secretase.

        Zhou, Rui; Yang, Guanghui; Guo, Xuefei; Zhou, Qiang; Lei, Jianlin; Shi, Yigong.

        SCIENCE 2019, 363 (6428): eaaw0930

      • Reconstitution and structure of a plant NLR resistosome conferring immunity.

        Wang, Jizong; Hu, Meijuan; Wang, Jia; Qi, Jinfeng; Han, Zhifu; Wang, Guoxun; Qi, Yijun; Wang, Hong-Wei; Zhou, Jian-Min; Chai, Jijie.

        SCIENCE 2019, 364 (6435): eaav5870

      • Cryo-EM structure of the mammalian ATP synthase tetramer bound with inhibitory protein IF1

        Gu, Jinke; Zhang, Laixing; Zong, Shuai; Guo, Runyu; Liu, Tianya; Yi, Jingbo; Wang, Peiyi; Zhuo, Wei; Yang, Maojun.

        SCIENCE 2019, 364 (6445): 1068-1075.

      • Resetting histone modifications during human parental-to-zygotic transition

        Xia, Weikun; Xu, Jiawei; Yu, Guang; Yao, Guidong; Xu, Kai; Ma, Xueshan; Zhang, Nan; Liu, Bofeng; Li, Tong; Lin, Zili; Chen, Xia; Li, Lijia; Wang, Qiujun; Shi, Dayuan; Shi, Senlin; Zhang, Yile; Song, Wenyan; Jin, Haixia; Hu, Linli; Bu, Zhiqin; Wang, Yang; Na, Jie; Xie, Wei; Sun, Ying-Pu.

        SCIENCE 2019, 365 (6451): 353-360.

      • The pigment-protein network of a diatom photosystem II-light-harvesting antenna supercomplex

        Pi, Xiong; Zhao, Songhao; Wang, Wenda; Liu, Desheng; Xu, Caizhe; Han, Guangye; Kuang, Tingyun; Sui, Sen-Fang; Shen, Jian-Ren..

        SCIENCE 2019, 365 (6452): eaax4406.

      • Migrasome formation is mediated by assembly of micron-scale tetraspanin macrodomains.

        Huang, Yuwei; Zucker, Ben; Zhang, Shaojin; Elias, Sharon; Zhu, Yun; Chen, Hui; Ding, Tianlun; Li, Ying; Sun, Yujie; Lou, Jizhong; Kozlov, Michael M.; Yu, Li.

        NATURE CELL BIOLOGY 2019, 21 (8): 991-1002.

      • Revealing lncRNA structures and interactions by sequencing-based approaches.

        Qian, Xingyang; Zhao, Jieyu; Yeung, Pui Yan; Zhang, Qiangfeng Cliff; Kwok, Chun Kit.

        TRENDS IN BIOCHEMICAL SCIENCES 2019, 44 (1): 33-52.

      • Bioactive functionalized monolayer graphene for high-resolution Cryo-Electron Microscopy.

        Liu, Nan; Zhang, Jincan; Chen, Yanan; Liu, Chuan; Zhang, Xing; Xu, Kui; Wen, Jie; Luo, Zhipu; Chen, Shulin; Gao, Peng; Jia, Kaicheng; Liu, Zhongfan; Peng, Hailin; Wang, Hong-Wei.

        JOURNAL OF THE AMERICAN CHEMICAL SOCIETY  2019, 141 (9): 4016-4025.

      • Histone modifications regulate chromatin compartmentalization by contributing to a phase separation mechanism.

        Wang, Liang; Gao, Yifei; Zheng, Xiangdong; Liu, Cuifang; Dong, Shuangshuang; Li, Ru; Zhang, Guanwei; Wei, Yixuan; Qu, Hongyuan; Li, Yuhan; Allis, C. David; Li, Guohong; Li, Haitao; Li, Pilong.

        MOLECULAR CELL 2019, 76 (4): 646 -659.

      • Mirror-image gene transcription and reverse transcription.

        Wang, Min; Jiang, Wenjun; Liu, Xianyu; Wang, Jiaxing; Zhang, Baochang; Fan, Chuyao; Liu, Lei; Pena-Alcantara, Giramnah; Ling, Jun-Jie; Chen, Ji; Zhu, Ting F.

        CHEM 2019, 5 (4): 848-857.



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